Effects of Endogenously and Exogenously Elevated Bilirubin on Myocardial Ischaemia Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Anaesthesia and myocardial ischaemia/reperfusion injury
Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice. This review will focus on the translation of the laboratory evidence of a...
متن کاملAnaesthesia and myocardial ischaemia/reperfusion injury.
Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice. This review will focus on the translation of the laboratory evidence of a...
متن کاملBilirubin: a promising antioxidant for ischaemia/reperfusion injury.
Dear Editors, We read with great interest the article by Ahanger et al. entitled ‘Pro-healing effects of bilirubin in open excisionwound model in rats’ (1). In this study, the authors hypothesised that bilirubin, which is known as a strong antioxidant, could be of potential therapeutic value in wound healing in open excision wound models in rats. To validate their hypothesis, they made a full-t...
متن کاملPharmacological interventions against myocardial ischaemia and reperfusion injury
Background: Although the concept of early restoration of coronary bloodflow constitutes an important factor to reduce the injury caused by myocardial ischaemia, reperfusion in itself can aggravate the damage to myocardial tissue, a phenomenon denoted myocardial reperfusion injury. Aims: To investigate whether two different pharmacological interventions, cyclosporine A (CsA) and the novel enkeph...
متن کاملEffects of MGC-0109, a slow-release sulphide donor, on myocardial ischaemia/reperfusion injury
Methods Ventilated, anaesthetized rats (4/group) were instrumented with vascular lines for drug/fluid administration. Following thoracotomy, the left anterior descending (LAD) coronary artery was ligated for 30 min. Just prior to reperfusion, animals received i.v. MGC-0109 (10 mg/kg bolus) or n-saline. MGC-0109-treated animals received a further 2.5 mg/kg infusion over 15 min. Control animals r...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2012
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.26.1_supplement.678.7